This 1852 game, published by W. & S.B. Ives of Salem, Massachusetts, will remind modern children and parents of Go Fish. It seems more likely that its designers simply imported images from the popular novel into an existing card game rather than tried to imagine a game that had some resonant connection to Uncle Tom's Cabin. As always, however, it is interesting to see what they decided to select from the story for the twenty playing cards.
Above are the front and back covers of the paper box the game came in.The Harriet Beecher Stowe Center Collection includes two copies of this game: Catalogue Numbers 90.2 and 69.105. Neither copy included all twenty of the hand-painted playing cards, but between the two a full set was reconstructed.